At one point, after examining a woman's blood, he discovers that the plague was caused by a bacterial infection, and dubs the germ "vampiris." In the book, the origin of the disease is unknown, and Robert Neville, the protagonist, spends much of the story searching for a cure. In the backstory of both the book and the movie, a plague spread across the globe that gave people rabies-like symptoms before turning them into vampire-like creatures. Regardless, the darkseekers were not created with a vaccine. In both the book and movie, there was an outbreak that turns people into "darkseekers." While Matheson's 1954 book had an impact on how both zombies and vampires would be depicted in future horror books and films, the fact that the defining characteristics of these movie villains is that they cannot be in sunlight places them firmly in the vampire section of the monster Venn diagram. In that period, Robert and his faithful dog, Sam, are padlocked within his apartment. The creatures it transforms can't emerge in the sunlight, so they stay hidden during the day only to come out and seek fresh blood between dusk and dawn. The disease was initially hyped as a cure for cancer (by Emma Thompson in an unbilled cameo) but it mutated and became a killer. Robert Neville (Will Smith), an ex-military scientist who was to some degree culpable for what happened to his race. New York has a human population of one: Dr. Kudos to the special effects wizards for using computers to so effectively depopulate the city. I Am Legend opens in 2012 New York City - the most deserted place on Earth. Here's an excerpt from Reel Reviews that describes the setting of "I Am Legend": In the movie version, the story takes place in New York in 2012 (an earlier film adaptation called "The Last Man on Earth" and starring Vincent Price is set in 1968). In the book, the story takes place in Los Angeles in the 1970s. Both works are set in the near future, but neither version takes place in 2021. The movie "I Am Legend" is based on a book of the same name by Richard Matheson that was published in 1954. The movie is about vampires - not zombies - and the outbreak was not caused by a vaccine. It's difficult to find a claim with as many factual errors as this one.
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